Article
Purification, crystallization and preliminary X-ray diffraction analysis of disease-related mutants of p97.
Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Nov 2009
Tang Wai Kwan, Li Dongyang, Esser Lothar, Xia Di
Abstract excerpt
The human type II AAA+ protein p97 participates in various cellular activities, presumably through its involvement in the ubiquitin-proteasome degradation pathway. Mutations in p97 have been implicated in patients with inclusion-body myopathy associated with Paget's disease of the bone and fronto...
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