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Article

Purification, crystallization and preliminary X-ray diffraction analysis of disease-related mutants of p97.

Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Nov 2009

Tang Wai Kwan, Li Dongyang, Esser Lothar, Xia Di

Abstract excerpt

The human type II AAA+ protein p97 participates in various cellular activities, presumably through its involvement in the ubiquitin-proteasome degradation pathway. Mutations in p97 have been implicated in patients with inclusion-body myopathy associated with Paget's disease of the bone and frontotemporal dementia (IBMPFD). In this work, three mutant p97 N-D1 fragments, R86A, R95G and R155H, were crystallized in...

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Identifiers

PMID: 19923742
DOI: 10.1107/S174430910904055X
PMCID: PMC2777050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Purification, crystallization and preliminary X-ray diffraction analysis of disease-related mutants of p97.PMID 19923742Read ↗

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