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Article

Structural and functional deviations in disease-associated p97 mutants.

Journal of structural biology - 1 Aug 2012

Tang Wai Kwan, Xia Di

Abstract excerpt

Missense mutations that occur at the interface between two functional domains in the AAA protein p97 lead to suboptimal performance in its enzymatic activity and impaired intracellular functions, causing human disorders such as inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia (IBMPFD). Much progress has been made in characterizing these mutants at cellular,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22579784
DOI: 10.1016/j.jsb.2012.04.024
PMCID: PMC4788498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Structural and functional deviations in disease-associated p97 mutants.PMID 22579784Read ↗

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