Article

Inhibition of the Rho/MRTF pathway improves the response of BRAF-resistant melanoma to PD1/PDL1 blockade

2023-12-21

Abstract excerpt

Metastatic cutaneous melanoma is a fatal skin cancer. Resistance to targeted and immune therapies limits the benefits of current treatments. Identifying and adding anti-resistance agents to current treatment protocols can potentially improve clinical responses. Myocardin-related transcription factor (MRTF) is a transcriptional coactivator whose activity is indirectly regulated by actin and the Rho family of GTPase...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e6965ccc-dc12-570b-a677-e825a37af8c2
DOI: 10.1101/2023.12.20.572555

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of the Rho/MRTF pathway improves the response of BRAF-resistant melanoma to PD1/PDL1 blockadeDOI 10.1101/2023.12.20.572555Read

Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: Implications for the involvement of pirinSemantic proximity Read

Inhibition of the Myocardin-Related Transcription Factor pathway increases efficacy of Trametinib in NRAS-mutant melanoma cell linesSemantic proximity Read

YAP1 drives aggressive and therapy resistant state in melanoma through reprogramming the chromatin and regulating immune evasive programsSemantic proximity Read

CDDO-Methyl Ester Inhibits BRAF Inhibitor Resistance and Remodels the Myeloid Compartment in BRAF-mutant MelanomaSemantic proximity Read

Mi-2β-targeted inhibition induces immunotherapy response in melanomaSemantic proximity Read

PTRF Confers Melanoma‐Acquired Drug Resistance Through the Upregulation of EGFRSemantic proximity Read

The c-Jun/RHOB/AKT pathway confers resistance ofBRAF-mutant melanoma cells to MAPK inhibitorsSemantic proximity Read

ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma.Semantic proximity Read

A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibitionSemantic proximity Read

Immune Responses to BRAF-Targeted Therapy in Melanoma: Is Targeted Therapy Immunotherapy?Semantic proximity Read

Rhpn2 promotes zebrafish melanoma development and aggressiveness <i>in vivo</i>Semantic proximity Read

A TLR7 agonist strengthens T and NK cell function during BRAF-targeted therapy in a preclinical melanoma model.Semantic proximity Read