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Article

Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation.

The EMBO journal - 1 Mar 2016

Kim Min Hwan, Kim Jongshin, Hong Hyowon, Lee Si-Hyung, Lee June-Koo, Jung Eunji, Kim Joon

Abstract excerpt

The activation of transcriptional coactivators YAP and its paralog TAZ has been shown to promote resistance to anti-cancer therapies. YAP/TAZ activity is tightly coupled to actin cytoskeleton architecture. However, the influence of actin remodeling on cancer drug resistance remains largely unexplored. Here, we report a pivotal role of actin remodeling in YAP/TAZ-dependent BRAF inhibitor resistance in BRAF V600E...

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Identifiers

PMID: 26668268
DOI: 10.15252/embj.201592081
PMCID: PMC4772854

Genes

BRAF
TESK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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