Article

Inhibition of the Myocardin-Related Transcription Factor pathway increases efficacy of Trametinib in NRAS-mutant melanoma cell lines

2019-09-19

Abstract excerpt

<h4>ABSTRACT</h4> The Ras/MEK/ERK pathway has been the primary focus of targeted therapies in melanoma; it is aberrantly activated in almost 80% of human cutaneous melanomas (∼50% BRAF V600 mutations and ∼30% NRAS mutations). While targeted therapies have yielded success in BRAF V600 mutant melanoma patients, such therapies have been ineffective in NRAS mutant melanomas in part due to their cytostatic effects a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d0dcc851-81b5-5e94-985e-3c65262af13f
DOI: 10.1101/773531

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of the Myocardin-Related Transcription Factor pathway increases efficacy of Trametinib in NRAS-mutant melanoma cell linesDOI 10.1101/773531Read

Inhibition of the Rho/MRTF pathway improves the response of BRAF-resistant melanoma to PD1/PDL1 blockadeSemantic proximity Read

Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.Semantic proximity Read

Targeting TBK1 inhibits migration and resistance to MEK inhibitors in mutant NRAS melanoma.Semantic proximity Read

Trametinib in the treatment of melanoma.Semantic proximity Read

Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: Implications for the involvement of pirinSemantic proximity Read

Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma.Semantic proximity Read

Targeting mutant NRAS signaling pathways in melanoma.Semantic proximity Read

Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma.Semantic proximity Read

Vertical inhibition of the MAPK pathway enhances therapeutic responses in NRAS-mutant melanoma.Semantic proximity Read

The role of MEK inhibitors in the treatment of metastatic melanoma.Semantic proximity Read

Resistance mechanisms to genetic suppression of mutant NRAS in melanoma.Semantic proximity Read

Genetic Drivers of Sensitivity or Resistance to RAS(ON) Multi-Selective Inhibitors in <i>NRAS</i> -Mutated MelanomaSemantic proximity Read