Article

Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: Implications for the involvement of pirin

2024-09-24

Abstract excerpt

<h4>Aim</h4> Overcoming therapy resistance is critical for effective melanoma control. Upregulation of Rho/MRTF signaling in human and mouse melanomas causes resistance to targeted therapies. Inhibition of this pathway by MRTFi, CCG-257081 resensitized resistant melanomas to BRAF and MEK inhibitors. It also prevented the development of resistance to vemurafenib (Vem). Here, we investigate the role of apoptosis an...

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Literature Corpus work: 74e3ba19-4910-526f-af5d-6df23e4e9c4b
DOI: 10.1101/2024.09.19.614009

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