Article
Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway.
Nature communications - 14 Nov 2017
Benedetti Elisa, Pučić-Baković Maja, Keser Toma, Wahl Annika, Hassinen Antti, Yang Jeong-Yeh, Liu Lin, Trbojević-Akmačić Irena, Razdorov Genadij, Štambuk Jerko, Klarić Lucija, Ugrina Ivo, Selman Maurice H J, Wuhrer Manfred, Rudan Igor, Polasek Ozren, Hayward Caroline, Grallert Harald, Strauch Konstantin, Peters Annette, Meitinger Thomas, Gieger Christian, Vilaj Marija, Boons Geert-Jan, Moremen Kelley W, Ovchinnikova Tatiana, Bovin Nicolai, Kellokumpu Sakari, Theis Fabian J, Lauc Gordan, Krumsiek Jan
Abstract excerpt
Immunoglobulin G (IgG) is a major effector molecule of the human immune response, and aberrations in IgG glycosylation are linked to various diseases. However, the molecular mechanisms underlying protein glycosylation are still poorly understood. We present a data-driven approach to infer reactions in the IgG glycosylation pathway using large-scale mass-spectrometry measurements. Gaussian graphical models are...
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