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Human genetic evidence supports MAP3K15 inhibition as a therapeutic strategy for diabetes

2021-11-15

Abstract excerpt

Diabetes mellitus is a chronic health condition that can result in significant end-organ complications and is estimated to impact at least 8.5% of the global adult population. Here, we performed gene-level collapsing analysis on exome sequences from 454,796 multi-ancestry UK Biobank participants to detect genetic associations with diabetes. Rare non-synonymous variants in GCK, GIGYF1, HNF1A , and HNF4A were signif...

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Literature Corpus work
e62c2262-3f65-571e-bfe0-6a6c68e57bf2
DOI
10.1101/2021.11.14.21266328
Open publication

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Human genetic evidence supports MAP3K15 inhibition as a therapeutic strategy for diabetesDOI 10.1101/2021.11.14.21266328
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