Whole-exome and Whole-genome Sequencing of 1097 Individuals with Type 1 Diabetes Reveals Novel Genes for Diabetic Kidney Disease

Abstract excerpt

<h4>Background and hypothesis</h4> Diabetic kidney disease (DKD) is a severe diabetic complication affecting one third of individuals with type 1 diabetes. Although several genes and common variants have been associated with DKD, much of the predicted inheritance remain unexplained. Here, we performed next-generation sequencing to assess whether low-frequency variants — single or aggregated — contribute to the mis...

Topics

Open a Topic to create a Post that cites this publication.

• Diabetes Mellitus, Type 1
• Diabetic Nephropathies
• Exome Sequencing
• Genetic Associations and Epidemiology
• Methyltransferases
• Polymorphism, Single Nucleotide
• Receptors, Tumor Necrosis Factor
• Whole Genome Sequencing

Identifiers and source

Literature Corpus work

0635ca65-e5ec-5d12-8b63-421f81f3d1a7

DOI

10.1101/2023.11.13.23298447