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Analysis of rare coding variants in 200,000 exome-sequenced subjects reveals novel genetic risk factors for type 2 diabetes.

Diabetes/metabolism research and reviews - 1 Jan 2022

Curtis David

Abstract excerpt

AIMS: The study aimed to elucidate the effects of rare genetic variants on the risk of type 2 diabetes (T2D). MATERIALS AND METHODS: Weighted burden analysis of rare variants was applied to a sample of 200,000 exome-sequenced participants in the UK Biobank project, of whom over 13,000 were identified as having T2D. Variant weights were allocated based on allele frequency and predicted effect, as informed by a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34216101
DOI: 10.1002/dmrr.3482

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