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Whole-exome and whole-genome sequencing of 1064 individuals with type 1 diabetes reveals novel genes for diabetic kidney disease.

Diabetologia - 1 Nov 2024

Haukka Jani K, Antikainen Anni A, Valo Erkka, Syreeni Anna, Dahlström Emma H, Lin Bridget M, Franceschini Nora, Krolewski Andrzej S, Harjutsalo Valma, Groop Per-Henrik, Sandholm Niina

Abstract excerpt

AIMS/HYPOTHESIS: Diabetic kidney disease (DKD) is a severe diabetic complication that affects one third of individuals with type 1 diabetes. Although several genes and common variants have been shown to be associated with DKD, much of the predicted inheritance remains unexplained. Here, we performed next-generation sequencing to assess whether low-frequency variants, extending to a minor allele frequency (MAF)...

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Share to Diabetes Mellitus, Type 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39103720
DOI: 10.1007/s00125-024-06241-1
PMCID: PMC11519100

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