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Weighted burden analysis in 200,000 exome-sequenced subjects characterises rare variant effects on risk of type 2 diabetes

2021-01-09

Abstract excerpt

Type 2 diabetes (T2D) is a disease for which both common genetic variants and environmental factors influence risk. A few genes have been identified in which very rare variants have large effects on risk and here we carry out a weighted burden analysis of rare variants in a sample of over 200,000 exome-sequenced participants in the UK Biobank project, of whom over 13,000 have T2D. Variant weights were allocated ba...

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Literature Corpus work
1e0b6c70-8546-57c4-8f27-cf48863f81ee
DOI
10.1101/2021.01.08.21249453
Open publication

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Weighted burden analysis in 200,000 exome-sequenced subjects characterises rare variant effects on risk of type 2 diabetesDOI 10.1101/2021.01.08.21249453
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