Article

Guanosine inhibits hepatitis C virus replication and increases indel frequencies, associated with altered intracellular nucleotide pools

2020-02-24

Abstract excerpt

In the course of experiments aimed at deciphering the inhibition mechanism of mycophenolic acid and ribavirin in hepatitis C virus (HCV) infection, we observed an inhibitory effect of the nucleoside guanosine (Gua). Here, we report that Gua and not the other standard nucleosides inhibits HCV replication in human hepatoma cells. Gua did not directly inhibit the in vitro polymerase activity of NS5B, but it modified...

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Identifiers and source

Literature Corpus work: e6289093-0111-5551-bf1e-e5fd50031367
DOI: 10.1101/2020.02.21.959536

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Guanosine inhibits hepatitis C virus replication and increases indel frequencies, associated with altered intracellular nucleotide poolsDOI 10.1101/2020.02.21.959536Read

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