Article

Use of CD122+ natural killer cell precursors for superior anti-leukemia responses

2022-10-24

Abstract excerpt

Acute Myeloid Leukemia (AML) is an aggressive blood cancer in adults. Intensive induction therapy successfully induces a complete response in up to 80% of the adult patients but a fraction of them is refractory or relapses. The fraction of non-responsive or relapsing patients is especially high amongst medically unfit and older patients, who cannot undergo aggressive chemotherapy treatment. Therefore, offering pat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e61eea87-8c64-5568-b6ba-d5e18a40f231
DOI: 10.1101/2022.10.24.513585

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Use of CD122+ natural killer cell precursors for superior anti-leukemia responsesDOI 10.1101/2022.10.24.513585Read

Natural killer cell therapy for hematologic malignancies: successes, challenges, and the futureSemantic proximity Read

Adoptive NK cell therapy in AML: progress and challengesSemantic proximity Read

High-Risk Leukemia: Past, Present, and Future Role of NK CellsSemantic proximity Read

Improving the Outcome of Leukemia by Natural Killer Cell-Based Immunotherapeutic StrategiesSemantic proximity Read

TREM2 Promotes Natural Killer Cell Development in CD3-CD122+NK1.1+ pNK CellsSemantic proximity Read

The NK-92 cell line—30 years later: its impact on natural killer cell research and treatment of cancerSemantic proximity Read

A Novel Feeder cell based on 4-1BBL and Membrane-bound IL-21/ IL-15 Induce Highly Expansion and Anti-tumor Effect of Natural Killer CellsSemantic proximity Read

CD56 as a marker of an ILC1-like population with NK cell properties that is functionally impaired in AMLSemantic proximity Read

Expansion, persistence and efficacy of donor memory-like NK cells for the treatment of post-transplant relapseSemantic proximity Read

Directed Differentiation of Mobilized Hematopoietic Stem and Progenitor Cells into Functional NK cells with Enhanced Antitumor Activity.Semantic proximity Read

Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients.Semantic proximity Read

A Novel Natural Killer Cell Expansion Technology for the Development of Cellular ImmunotherapiesSemantic proximity Read