Article

Lysionotin enhances circadian rhythm and accelerates the recovery of DSS-induced colitis in mice by targeting the circadian clock component RORα

2025-10-21

Abstract excerpt

<h4>Background: </h4> and Purpose : Circadian clock disruptions are implicated in various pathological processes, including inflammatory diseases such as ulcerative colitis (UC). Restoring or enhancing the molecular circadian clock represents a promising therapeutic strategy. Lysionotin (LYS), a natural polymethoxyflavone, was investigated for its potential role in modulating circadian rhythms and mitigating colit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e605c822-c973-5231-805d-7cad541475c6
DOI: 10.22541/au.176106970.02853906/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lysionotin enhances circadian rhythm and accelerates the recovery of DSS-induced colitis in mice by targeting the circadian clock component RORαDOI 10.22541/au.176106970.02853906/v1Read

Circadian Regulator PER2 Protects Against Epithelial Necroptosis in Ulcerative Colitis via the STAT1–ZBP1 AxisSemantic proximity Read

Unraveling the physiological roles of retinoic acid receptor-related orphan receptor αSemantic proximity Read

Circadian time-dependent effects of experimental colitis on theophylline disposition and toxicitySemantic proximity Read

Circadian stabilization loop: the regulatory hub and therapeutic target promoting circadian resilience and physiological healthSemantic proximity Read

The Circadian Clock Gene BMAL1 Coordinates Intestinal RegenerationSemantic proximity Read

The Circadian Clock Controls Hepatic Stellate Cell Activation in Liver Fibrosis via a BMAL1/CK1ε/REV-ERBα/Transgelin Signaling PathwaySemantic proximity Read

Circadian Clock Manipulation for Cancer Prevention and Control and the Relief of Cancer SymptomsSemantic proximity Read

Chronoefficacy of the herbal medicines Puerariae radix and Coptidis rhizoma in mice: A potential role of REV-ERBαSemantic proximity Read

Genetic disruption of the circadian gene Bmal1 in the intestinal epithelium reduces colonic inflammationSemantic proximity Read

Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine.Semantic proximity Read

Drugging the circadian clock feedback cycle to ameliorate cartilage degenerationSemantic proximity Read