Article

Chronoefficacy of the herbal medicines Puerariae radix and Coptidis rhizoma in mice: A potential role of REV-ERBα

2021-01-22

Abstract excerpt

<h4>Background: </h4> Identifying drugs with circadian time-dependent efficacy (chronoefficacy) and understanding the underlying mechanisms would help to improve drug treatment outcome. Here, we aimed to determine chronoefficacy of the herbal medicines Puerariae radix (PR) and Coptidis rhizoma (CR), and investigate a potential role of REV-ERBα as a drug target in generating chronoefficacy. Materials and methods P...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6321559b-77ad-5f82-a3fb-f92fa6f89c74
DOI: 10.21203/rs.3.rs-151541/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chronoefficacy of the herbal medicines Puerariae radix and Coptidis rhizoma in mice: A potential role of REV-ERBαDOI 10.21203/rs.3.rs-151541/v1Read

Circadian time-dependent effects of experimental colitis on theophylline disposition and toxicitySemantic proximity Read

Morning vs. Evening: The Temporal Differences of Ginger's Efficacy in LungSemantic proximity Read

Circadian stabilization loop: the regulatory hub and therapeutic target promoting circadian resilience and physiological healthSemantic proximity Read

Lysionotin enhances circadian rhythm and accelerates the recovery of DSS-induced colitis in mice by targeting the circadian clock component RORαSemantic proximity Read

СhronobioticsDB: The Database of Drugs and Compounds Modulating Circadian RhythmsSemantic proximity Read

Circadian stabilization loop: the regulatory hub and therapeutic target promoting circadian resilience and physiological healthSemantic proximity Read

Role of circadian transcription factor REV-ERB in cardiovascular diseases: a reviewSemantic proximity Read

Berberine ameliorates chronic relapsing dextran sulfate sodium-induced colitis in C57BL/6 mice by suppressing Th17 responses.Semantic proximity Read

Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer’s diseaseSemantic proximity Read

Cycloastragenol: An exciting novel candidate for age‑associated diseases (Review)Semantic proximity Read

Genetic disruption of the circadian gene Bmal1 in the intestinal epithelium reduces colonic inflammationSemantic proximity Read

Effect of folic acid-Echinacea-derived alkylamides liposomes on mice with ulcerative colitisSemantic proximity Read