Stepwise approach to oocyte depletion in <i>Sry</i> mutated XY female mice

Abstract excerpt

Little is known regarding the mechanisms underlying infertility in male-to-female sex-reversed females. To gain a better understanding of germ cell dysfunction in this condition, we produced XY sry − -females via the CRISPR/Cas9 system in C57BL/6 inbred strain mice. Mutant mice showed severe attrition of germ cells during foetal development, resulting in depletion of ovarian germ cells before sexual maturation....

Topics

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• Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
• Meiosis
• Reproductive Biology and Fertility
• RNA-Seq
• Sexual Differentiation and Disorders
• Single-Cell Analysis
• Single-Cell Gene Expression Analysis
• Sperm and Testicular Function

Identifiers and source

Literature Corpus work

e5f84478-c769-571e-8bbe-793fce4e3080

DOI

10.1101/146571