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Regulation of male sex determination: genital ridge formation and Sry activation in mice

19 Aug 2014

Abstract excerpt

Sex determination is essential for the sexual reproduction to generate the next generation by the formation of functional male or female gametes. In mammals, primary sex determination is commenced by the presence or absence of the Y chromosome, which controls the fate of the gonadal primordium. The somatic precursor of gonads, the genital ridge is formed at the mid-gestation stage and gives rise to one of two...

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PMID: 25139092
DOI: 10.1007/s00018-014-1703-3

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