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Genetic studies in mice directly link oocytes produced during adulthood to ovarian function and natural fertility

24 Aug 2017

Abstract excerpt

Multiple labs have reported that mammalian ovaries contain oogonial stem cells (OSCs), which can differentiate into oocytes that fertilize to produce offspring. However, the physiological relevance of these observations to adult ovarian function is unknown. Here we performed targeted and reversible ablation of premeiotic germ cells undergoing differentiation into oocytes in transgenic mice expressing the suicide...

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PMID: 28855574
DOI: 10.1038/s41598-017-10033-6

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