Article

Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitor

2020-02-04

Abstract excerpt

<h4>ABSTRACT</h4> Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of intrinsic, innate and adaptive viral immune evasion. Here, we employed multiplexed tandem mass tag-based proteomics to characterise host proteins targeted for degradation late during HCMV infection. This approach revealed that mixed lineage kinase domain-like protein (MLKL), a key terminal mediator of cellular necropto...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e5e43d17-ee44-5c19-b52c-1b77cda179a2
DOI: 10.1101/2020.02.03.928564

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitorDOI 10.1101/2020.02.03.928564Read

Human cytomegalovirus triggered necroptosis is suppressed by sequestration of MLKL in the nucleus of infected monocytesSemantic proximity Read

High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion MechanismsSemantic proximity Read

Virion Proteomics of Genetically Intact HCMV Reveals a Novel Regulator of Envelope Glycoprotein Composition that Protects Against Humoral ImmunitySemantic proximity Read

Human cytomegalovirus UL38 protein blocks apoptosis.Semantic proximity Read

Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functionsSemantic proximity Read

Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complexSemantic proximity Read

The life cycle and pathogenesis of human cytomegalovirus infection: lessons from proteomicsSemantic proximity Read

Human Cytomegalovirus Glycoprotein UL141 Targets the TRAIL Death Receptors to Thwart Host Innate Antiviral DefensesSemantic proximity Read

Cytomegalovirus Biology Viewed Through a Cell Death Suppression LensSemantic proximity Read

Human cytomegalovirus UL36 inhibits IRF3-dependent immune signaling to counterbalance its immunoenhancement as apoptotic inhibitorSemantic proximity Read

ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathwaysSemantic proximity Read

Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complexSemantic proximity Read