Article

Virion Proteomics of Genetically Intact HCMV Reveals a Novel Regulator of Envelope Glycoprotein Composition that Protects Against Humoral Immunity

2024-11-30

Abstract excerpt

Human cytomegalovirus (HCMV) is a clinically important herpesvirus that has co-evolved for millions of years with its human host, and establishes lifelong persistent infection. A substantial proportion of its 235kb genome is dedicated to manipulating host immunity through targeting antiviral host proteins for degradation or relocalisation. Quantitative proteomics of the infected cell has extensively characterised...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e726913-f062-5e4c-b717-ad2f58d25dca
DOI: 10.1101/2024.11.29.626001

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Virion Proteomics of Genetically Intact HCMV Reveals a Novel Regulator of Envelope Glycoprotein Composition that Protects Against Humoral ImmunityDOI 10.1101/2024.11.29.626001Read

Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions.Semantic proximity Read

The structure of cytomegalovirus immune modulator UL141 highlights structural Ig-fold versatility for receptor binding.Semantic proximity Read

Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complexSemantic proximity Read

Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitorSemantic proximity Read

The human cytomegalovirus protein UL147A downregulates the most prevalent MICA allele: MICA*008, to evade NK cell-mediated killingSemantic proximity Read

Human Cytomegalovirus Glycoprotein UL141 Targets the TRAIL Death Receptors to Thwart Host Innate Antiviral DefensesSemantic proximity Read

The life cycle and pathogenesis of human cytomegalovirus infection: lessons from proteomicsSemantic proximity Read

Pathogen at the Gates: Human Cytomegalovirus Entry and Cell TropismSemantic proximity Read

NKG2D Ligand MICA Is Retained in the<i>cis</i>-Golgi Apparatus by Human Cytomegalovirus Protein UL142Semantic proximity Read

Quantitative Temporal Viromics: An Approach to Investigate Host-Pathogen InteractionSemantic proximity Read

High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion MechanismsSemantic proximity Read

Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complexSemantic proximity Read