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Article

Human cytomegalovirus UL38 protein blocks apoptosis.

Journal of virology - 1 Apr 2007

Terhune Scott, Torigoi Emi, Moorman Nathaniel, Silva Maria, Qian Zhikang, Shenk Thomas, Yu Dong

Abstract excerpt

Apoptosis is an innate cellular defense response to viral infection. The slow-replicating human cytomegalovirus (HCMV) blocks premature death of host cells prior to completion of the infection cycle. In this study, we report that the HCMV UL38 gene encodes a cell death inhibitory protein. A mutant virus lacking the pUL38 coding sequence, ADdlUL38, grew poorly in human fibroblasts, failed to accumulate viral DNA...

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Identifiers

PMID: 17202209
DOI: 10.1128/JVI.02124-06
PMCID: PMC1866066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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