Article

Human cytomegalovirus triggered necroptosis is suppressed by sequestration of MLKL in the nucleus of infected monocytes

2025-04-28

Abstract excerpt

The systemic spread of human cytomegalovirus (HCMV) is associated with severe morbidity and mortality in immunocompromised and immunonaïve patients. Hematogenous dissemination of HCMV to different organ sites is facilitated by peripheral blood monocytes. Circulating monocytes have a short lifespan due, in part, to their intrinsic biological programming to initiate caspase 8-mediated apoptosis upon entry into the c...

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Literature Corpus work: 221e15cb-dcf9-595d-b92f-73fd6229d759
DOI: 10.1101/2025.04.28.651015

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