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Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions

24 Dec 2019

Abstract excerpt

Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating >900 human proteins during viral replication and degrading ≥133 proteins shortly after infection. The mechanism of degradation of most host proteins remains unresolved, and the functions of many viral proteins are incompletely characterised. We performed a mass spectrometry-based interactome analysis of 169 tagged, stably-expressed...

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PMID: 31873071
DOI: 10.7554/elife.49894

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