Article

High-sensitivity vision restoration via ectopic expression of chimeric rhodopsin in mice

2020-09-18

Abstract excerpt

Photoreception requires amplification by mammalian rhodopsin through G protein activation, which requires a visual cycle. To achieve this in retinal gene therapy, we incorporated human rhodopsin cytoplasmic loops into Gloeobacter rhodopsin, thereby generating Gloeobacter and human chimeric rhodopsin (GHCR). In a murine model of inherited retinal degeneration, we induced retinal GHCR expression by intravitreal in...

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Identifiers and source

Literature Corpus work: e5c39146-3c97-5a15-a38f-6fcd28ea8ea1
DOI: 10.1101/2020.09.17.301523

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