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Article

Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002

Kijas James W, Cideciyan Artur V, Aleman Tomas S, Pianta Michael J, Pearce-Kelling Susan E, Miller Brian J, Jacobson Samuel G, Aguirre Gustavo D, Acland Gregory M

Abstract excerpt

Rhodopsin is the G protein-coupled receptor that is activated by light and initiates the transduction cascade leading to night (rod) vision. Naturally occurring pathogenic rhodopsin (RHO) mutations have been previously identified only in humans and are a common cause of dominantly inherited blindness from retinal degeneration. We identified English Mastiff dogs with a naturally occurring dominant retinal...

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Identifiers

PMID: 11972042
DOI: 10.1073/pnas.082714499
PMCID: PMC122948

Genes

RHO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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