Article

Bipolar Cell Targeted Optogenetic Gene Therapy Restores Parallel Retinal Signaling And High-Level Vision In The Degenerated Retina

2022-02-02

Abstract excerpt

<title>Abstract</title> <p>Optogenetic gene therapies to restore vision are in clinical trials. Whilst current clinical approaches target the ganglion cells, the output neurons of the retina, new molecular tools enable efficient targeting of the first order retinal interneurons, the bipolar cells, with the potential to restore a higher quality of vision. Here we investigate retinal signaling and behavioral vision...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1b2af0e-5da9-55ee-9b7f-89fa0caa4c86
DOI: 10.21203/rs.3.rs-999738/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bipolar Cell Targeted Optogenetic Gene Therapy Restores Parallel Retinal Signaling And High-Level Vision In The Degenerated RetinaDOI 10.21203/rs.3.rs-999738/v1Read

Enhanced restoration of visual code after targeting on bipolar cells compared to retinal ganglion cells with optogenetic therapySemantic proximity Read

Interaction between native and prosthetic visual responses in optogenetic visual restorationSemantic proximity Read

Selective Block of Upregulated Kv1.3 Potassium Channels in ON-Bipolar Cells of the Blind Retina Enhances Optogenetically Restored SignalingSemantic proximity Read

A synthetic opsin restores vision in patients with severe retinal degeneration.Semantic proximity Read

Optogenetic therapy: High spatiotemporal resolution and pattern recognition compatible with vision restoration in non-human primatesSemantic proximity Read

Restoration of visual function by transplantation of optogenetically engineered photoreceptorsSemantic proximity Read

Ectopic expression of two cone opsins in mouse RGCs results in opposite responses to light stimulation, likely due to differential G protein activationSemantic proximity Read

Retinal optogenetic therapies: clinical criteria for candidacy.Semantic proximity Read

Optogenetic Targeting of AII Amacrine Cells restores Retinal Computations performed by the Inner RetinaSemantic proximity Read

High-sensitivity vision restoration via ectopic expression of chimeric rhodopsin in miceSemantic proximity Read

Regeneration of Functional Retinal Ganglion Cells by Neuronal Identity ReprogrammingSemantic proximity Read

A metabotropic glutamate receptor agonist enhances visual signal fidelity in a mouse model of retinitis pigmentosaSemantic proximity Read