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Targeting THOC2-Mediated mRNA Export Induces PARP Inhibitor Vulnerability in DNA Repair-Competent Hepatocellular Carcinoma

2026-05-19

Abstract excerpt

Hepatocellular carcinoma (HCC) remains a lethal malignancy with limited therapeutic options. While Poly (ADP-ribose) polymerase inhibitors (PARPi) exploit synthetic lethality in tumors with DNA repair defects, their clinical utility in HCC is hindered by the low prevalence of canonical repair gene mutations and the enhancing DNA repair capacity. Through proteomic analysis of two independent cohorts ( n =260), we...

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Literature Corpus work
e57aef8f-1aa4-5906-8a6e-c8fe63de261a
DOI
10.64898/2026.05.17.725613
Open publication

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Targeting THOC2-Mediated mRNA Export Induces PARP Inhibitor Vulnerability in DNA Repair-Competent Hepatocellular CarcinomaDOI 10.64898/2026.05.17.725613
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