Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting NAT10 attenuates homologous recombination via destabilizing DNA:RNA hybrids and overcomes PARP inhibitor resistance in cancers

23 Mar 2025

Abstract excerpt

AIMS: RNA metabolism has been extensively studied in DNA double-strand break (DSB) repair. The RNA acetyltransferase N-acetyltransferase 10 (NAT10)-mediated N4-acetylcytidine (ac4C) modification in DSB repair remains largely elusive. In this study, we aim to decipher the role for ac4C modification by NAT10 in DSB repair in hepatocellular carcinoma (HCC). METHODS: Laser micro-irradiation and chromatin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40132530
DOI: 10.1016/j.drup.2025.101241

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting NAT10 attenuates homologous recombination via destabilizing DNA:RNA hybrids and overcomes PARP inhibitor resistance in cancersPMID 40132530Read ↗

TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinomaSemantic proximity Read ↗

DUSP12 regulates NAT10-mediated RNA acetylation to modulate DNA repair and therapeutic response in hepatocellular carcinomaSemantic proximity Read ↗

Biological Function and Mechanism of NAT10 in CancerSemantic proximity Read ↗

Emerging role of N-acetyltransferase 10 in diseases: RNA ac4C modification and beyondSemantic proximity Read ↗

Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damageSemantic proximity Read ↗

Targeting THOC2-Mediated mRNA Export Induces PARP Inhibitor Vulnerability in DNA Repair-Competent Hepatocellular CarcinomaSemantic proximity Read ↗

Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitorsSemantic proximity Read ↗

Nucleolytic processing of abasic sites underlies PARP inhibitor hypersensitivity in ALC1-deficient BRCA mutant cancer cells.Semantic proximity Read ↗

PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stressSemantic proximity Read ↗

Research progress on NAT10-mediated acetylation in normal development and diseaseSemantic proximity Read ↗

NAT10 promotes chemoresistance of melanoma through regulating N4-acetylcytidine modification of DDX41 and ZNF746 mRNASemantic proximity Read ↗

Histone methyltransferase KMT5C drives liver cancer progression and directs therapeutic response to PARP inhibitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.