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Sporadic ALS induced pluripotent stem cell derived neurons reveal hallmarks of TDP-43 loss of function

2 Aug 2025

Abstract excerpt

Nuclear loss and cytoplasmic buildup of the RNA-binding protein TDP-43 is a hallmark of ALS and related disorders. While studies using artificial TDP-43 depletion in neurons have revealed changes in gene expression and splicing, their relevance to actual patients remained unclear. Induced pluripotent stem cell (iPSC)-derived neurons (iPSNs) from 180 individuals, including controls, C9orf72 ALS/FTD, and sporadic...

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Amyotrophic Lateral Sclerosis Research
Neurogenetic and Muscular Disorders Research
Pluripotent Stem Cells Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40753166
DOI: 10.1038/s41467-025-62482-7

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