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Pathological α-syn aggregation is mediated by glycosphingolipid chain length and the physiological state of α-syn in vivo

6 Dec 2021

Abstract excerpt

mutations exhibit neurodegeneration, and the factors that influence neurological phenotypes are unknown. We find that α-synuclein (α-syn) neuropathology induced by GCase depletion depends on neuronal maturity, the physiological state of α-syn, and specific accumulation of long-chain glycosphingolipid (GSL) GCase substrates. Reduced GCase activity does not initiate α-syn aggregation in neonatal mice or immature...

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PMID: 34893541
DOI: 10.1073/pnas.2108489118

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