Article

Frontal Brain Injury Reduces Sensitivity to Reward-Predictive Cues and Remodels the Nucleus Accumbens

2026-04-19

Abstract excerpt

Traumatic brain injuries (TBIs) are more than mere lesions and generate a persistent secondary pathology. This, combined with functional reorganization of circuits post-injury, may explain the increased risk for psychiatric disorders in patients with TBI. In the current studies, we demonstrate that frontal TBI changed the Pavlovian behavioral response to reinforcer-predicting cues and reduced the motivational valu...

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Literature Corpus work: e53ea7df-6aba-55a2-9eaf-1dbad49db3b7
DOI: 10.64898/2026.04.17.718474

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