Convergent coexpression reveals shared biological mechanisms underlying common and rare variant risk in six neuropsychiatric disorders.

Abstract excerpt

Genome-wide association studies (GWAS) and large-scale rare variant burden analyses have identified both common and rare loss-of-function variants associated with neuropsychiatric and neurodegenerative disorders. Yet, the shared biological processes influenced by both classes of variation remain poorly characterized. In this study, we utilized transcriptomic data from 933 post-mortem brain samples to identify...

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