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Article

Oncolytic Poliovirus Against Malignant Glioma

1 Sept 2011

Abstract excerpt

In cancerous cells, physiologically tight regulation of protein synthesis is lost, contributing to uncontrolled growth and proliferation. We describe a novel experimental cancer therapy approach based on genetically recombinant poliovirus that targets an intriguing aberration of translation control in malignancy. This strategy is based on the confluence of several factors enabling specific and efficacious cancer...

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Identifiers

PMID: 21984883
DOI: 10.2217/fvl.11.76

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