Article
Oncolytic Viro-Immunotherapy: An Emerging Option in the Treatment of Gliomas.
Frontiers in immunology - 1 Jan 2021
Zeng Jiayi, Li Xiangxue, Sander Max, Zhang Haipeng, Yan Guangmei, Lin Yuan
Abstract excerpt
The prognosis of malignant gliomas remains poor, with median survival fewer than 20 months and a 5-year survival rate merely 5%. Their primary location in the central nervous system (CNS) and its immunosuppressive environment with little T cell infiltration has rendered cancer therapies mostly ineffective, and breakthrough therapies such as immune checkpoint inhibitors (ICIs) have shown limited benefit. However,...
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