Article

Single nucleus transcriptomics, pharmacokinetics, and pharmacodynamics of combined CDK4/6 and mTOR inhibition in a phase 0/1 trial of recurrent high-grade glioma

2024-06-07

Abstract excerpt

<h4>ABSTRACT</h4> Outcomes for adult patients with a high-grade glioma continue to be dismal and new treatment paradigms are urgently needed. To optimize the opportunity for discovery, we performed a phase 0/1 dose-escalation clinical trial that investigated tumor pharmacokinetics, pharmacodynamics, and single nucleus transcriptomics following combined ribociclib (CDK4/6 inhibitor) and everolimus (mTOR inhibitor)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e5252349-136b-5094-8067-e68062044a90
DOI: 10.1101/2024.06.07.24308439

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single nucleus transcriptomics, pharmacokinetics, and pharmacodynamics of combined CDK4/6 and mTOR inhibition in a phase 0/1 trial of recurrent high-grade gliomaDOI 10.1101/2024.06.07.24308439Read

Single-nucleus expression characterization of non-enhancing region of recurrent high-grade gliomaSemantic proximity Read

Targeting Radiation-Induced Glioma-Initiating Cells in Patient-Derived GlioblastomaSemantic proximity Read

Analysis of single-cell RNA-sequencing data to identify quiescent and proliferating neural cell populations in GlioblastomaSemantic proximity Read

Epigenomic perturbation of novel <i>EGFR</i> enhancers reduces the proliferative and invasive capacity of glioblastoma and increases sensitivity to temozolomideSemantic proximity Read

Enhancing CDK4/6 inhibitor therapy for medulloblastoma using nanoparticle delivery and scRNA-seq-guided combination with sapanisertibSemantic proximity Read

Contributions to Drug Resistance in Glioblastoma Derived from Malignant Cells in the Sub-Ependymal ZoneSemantic proximity Read

Functional Genomic Screens Reveal RBBP4 as a Key Regulator of Cell Cycle Progression in TMZ-Resistant GlioblastomaSemantic proximity Read

Image-Guided Mesenchymal Stem Cell Sodium Iodide Symporter (NIS) Radionucleotide Therapy for GlioblastomaSemantic proximity Read

Exploring Regorafenib Responsiveness and Uncovering Molecular Mechanisms in Recurrent Glioblastoma Tumors Through Longitudinal In Vitro SamplingSemantic proximity Read

Metabolic Imaging and Molecular Signatures Reveal Metabolic Phenotypes in Recurrent Glioblastoma.Semantic proximity Read

MR-Guided Focused Ultrasound-Enhanced Liquid Biopsy (Sonobiopsy) for the Definitive Differentiation of True Progression from Pseudoprogression in Glioblastoma: A Prospective Phase II Clinical TrialSemantic proximity Read

Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug resistant gliomasSemantic proximity Read