Single-Cell Analysis Reveals Transcriptomic Features of Drug-Tolerant Persisters and Stromal Adaptation in a Patient-Derived EGFR-Mutated Lung Adenocarcinoma Xenograft Model.

doi:10.1016/j.jtho.2022.12.003

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Article

Single-Cell Analysis Reveals Transcriptomic Features of Drug-Tolerant Persisters and Stromal Adaptation in a Patient-Derived EGFR-Mutated Lung Adenocarcinoma Xenograft Model.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2023

Moghal Nadeem, Li Quan, Stewart Erin L, Navab Roya, Mikubo Masashi, D'Arcangelo Elisa, Martins-Filho Sebastiao N, Raghavan Vibha, Pham Nhu-An, Li Ming, Shepherd Frances A, Liu Geoffrey, Tsao Ming-Sound

Abstract excerpt

INTRODUCTION: Targeted therapies require life-long treatment, as drug discontinuation invariably leads to tumor recurrence. Recurrence is mainly driven by minor subpopulations of drug-tolerant persister (DTP) cells that survive the cytotoxic drug effect. In lung cancer, DTP studies have mainly been conducted with cell line models. METHODS: We conducted an in vivo DTP study using a lung adenocarcinoma...

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PMID: 36535627
DOI: 10.1016/j.jtho.2022.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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