Article

Evolutionary arms race between virus and host drives genetic diversity in bat SARS related coronavirus spike genes

2020-05-14

Abstract excerpt

The Chinese horseshoe bat ( Rhinolophus sinicus ), reservoir host of severe acute respiratory syndrome coronavirus (SARS-CoV), carries many bat SARS-related CoVs (SARSr-CoVs) with high genetic diversity, particularly in the spike gene. Despite these variations, some bat SARSr-CoVs can utilize the orthologs of human SARS-CoV receptor, angiotensin-converting enzyme 2 (ACE2), for entry. It is speculated that the int...

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Literature Corpus work: e504b436-26ce-5ba4-954c-b69136b4b7f9
DOI: 10.1101/2020.05.13.093658

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