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Article

Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2.

PLoS pathogens - 1 Apr 2021

Mou Huihui, Quinlan Brian D, Peng Haiyong, Liu Guanqun, Guo Yan, Peng Shoujiao, Zhang Lizhou, Davis-Gardner Meredith E, Gardner Matthew R, Crynen Gogce, DeVaux Lindsey B, Voo Zhi Xiang, Bailey Charles C, Alpert Michael D, Rader Christoph, Gack Michaela U, Choe Hyeryun, Farzan Michael

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein mediates infection of cells expressing angiotensin-converting enzyme 2 (ACE2). ACE2 is also the viral receptor of SARS-CoV (SARS-CoV-1), a related coronavirus that emerged in 2002-2003. Horseshoe bats (genus Rhinolophus) are presumed to be the original reservoir of both viruses, and a SARS-like coronavirus, RaTG13, closely related...

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Identifiers

PMID: 33836016
DOI: 10.1371/journal.ppat.1009501
PMCID: PMC8059821

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