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Evolution of SARS-CoV-2 Spikes shapes their binding affinities to animal ACE2 orthologs.

Microbiology spectrum - 12 Dec 2023

Yao Weitong, Li Yujun, Ma Danting, Hou Xudong, Wang Haimin, Tang Xiaojuan, Cheng Dechun, Zhang He, Du Chengzhi, Pan Hong, Li Chao, Lin Hua, Sun Mengsi, Ding Qiang, Wang Yingjie, Gao Jiali, Zhong Guocai

Abstract excerpt

IMPORTANCE: Spike-receptor interaction is a critical determinant for the host range of coronaviruses. In this study, we investigated the SARS-CoV-2 WHU01 strain and five WHO-designated SARS-CoV-2 variants of concern (VOCs), including Alpha, Beta, Gamma, Delta, and the early Omicron variant, for their Spike interactions with ACE2 proteins of 18 animal species. First, the receptor-binding domains (RBDs) of Alpha,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37943512
DOI: 10.1128/spectrum.02676-23
PMCID: PMC10715038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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