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Evolutionary Arms Race between Virus and Host Drives Genetic Diversity in Bat Severe Acute Respiratory Syndrome-Related Coronavirus Spike Genes.

Journal of virology - 29 Sept 2020

Guo Hua, Hu Bing-Jie, Yang Xing-Lou, Zeng Lei-Ping, Li Bei, Ouyang Songying, Shi Zheng-Li

Abstract excerpt

The Chinese horseshoe bat (Rhinolophus sinicus), reservoir host of severe acute respiratory syndrome coronavirus (SARS-CoV), carries many bat SARS-related CoVs (SARSr-CoVs) with high genetic diversity, particularly in the spike gene. Despite these variations, some bat SARSr-CoVs can utilize the orthologs of the human SARS-CoV receptor, angiotensin-converting enzyme 2 (ACE2), for entry. It is speculated that the...

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Identifiers

PMID: 32699095
DOI: 10.1128/JVI.00902-20
PMCID: PMC7527062

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