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High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease

2020-02-11

Abstract excerpt

<h4>Background</h4> Genetic variants can be used to prioritize risk factors as potential therapeutic targets via Mendelian randomization (MR). An agnostic statistical framework using Bayesian model averaging (MR-BMA) can disentangle the causal role of correlated risk factors with shared genetic predictors. Here, our objective is to identify lipoprotein measures as mediators between lipid-associated genetic variant...

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Literature Corpus work
e4e221d0-edea-5f70-9b2a-e601e1cbbdf6
DOI
10.1101/2020.02.10.20021691
Open publication

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High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery diseaseDOI 10.1101/2020.02.10.20021691
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