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Article

Loss of FOXP3 function causes expansion of two pools of autoreactive T cells in patients with IPEX syndrome

2022-07-11

Abstract excerpt

The monogenic autoimmune disease Immunedysregulation polyendocrynopathy entheropathy X-linked syndrome (IPEX) has elucidated the essential function of the transcription factor FOXP3 and of thymic-derived regulatory T (Treg) cells in controlling autoimmunity. However, the presence of autoreactive T cells in IPEX remains undetermined, thus representing a crucial gap in understanding the origin of autoimmunity in a F...

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Literature Corpus work
a8f21857-8445-57ef-b5ba-69933e035bdc
DOI
10.1101/2022.07.10.499494
Open publication

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Loss of FOXP3 function causes expansion of two pools of autoreactive T cells in patients with IPEX syndromeDOI 10.1101/2022.07.10.499494
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