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Article

Metabolic reprogramming of fetal hematopoietic stem and progenitor cells by maternal obesity

14 Apr 2025

Abstract excerpt

Maternal obesity, often linked to the consumption of a high-fat Western-style diet (WSD), poses significant risks to both maternal and fetal health. This review explores the impact of maternal obesity on fetal hematopoietic stem and progenitor cells (HSPCs), highlighting how metabolic and inflammatory shifts in the maternal environment affect HSPC proliferation, differentiation, and long-term immune system...

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Identifiers

PMID: 40678471
DOI: 10.3389/frhem.2025.1575143

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