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A Randomised Controlled Trial of Nasal Immunisation with Live Virulence Attenuated<i>Streptococcus pneumoniae</i>Strains using Human Infection Challenge

2023-04-14

Abstract excerpt

<h4>Rationale</h4> Pneumococcal pneumonia remains a global health problem. Pneumococcal colonisation increases local and systemic protective immunity, suggesting nasal administration of live attenuated S. pneumoniae strains could help prevent infections. <h4>Objectives</h4> We used a controlled human infection model to investigate whether nasopharyngeal colonisation with attenuated S. pneumoniae strains protected...

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Literature Corpus work
e4868138-6c3d-5042-b674-0d5a1b3a8ad9
DOI
10.1101/2023.04.14.23288224
Open publication

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A Randomised Controlled Trial of Nasal Immunisation with Live Virulence Attenuated<i>Streptococcus pneumoniae</i>Strains using Human Infection ChallengeDOI 10.1101/2023.04.14.23288224
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