Article

<i>E2F3</i> amplification primes bladder cancer cells for premature mitosis

2025-09-18

Abstract excerpt

The E2F–RB pathway controls the G1/S checkpoint, and tumors often bypass it through RB1 or CDKN2A loss. Unlike these lesions, E2F3 amplification drives persistent excessive E2F-dependent transcription through S and G2 phases. This oncogene is frequently amplified in for example bladder cancer, but its impact on the cancer cell cycle remains unclear. Using isogenic bladder cancer models and patient data, we show...

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Literature Corpus work: e4746d85-4f19-5f8b-992a-afa39bf26cb9
DOI: 10.1101/2025.09.16.676590

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