Article
Induction of centrosome amplification and chromosome instability in human bladder cancer cells by p53 mutation and cyclin E overexpression.
Cancer research - 15 Jul 2004
Kawamura Kenji, Izumi Hideki, Ma Zhiyong, Ikeda Ryosuke, Moriyama Manabu, Tanaka Tatsuro, Nojima Takayuki, Levin Linda S, Fujikawa-Yamamoto Kohzaburo, Suzuki Koji, Fukasawa Kenji
Abstract excerpt
Centrosome amplification frequently occurs in human cancers and is a major cause of chromosome instability (CIN). In mouse cells, centrosome amplification can be readily induced by loss or mutational inactivation of p53. In human cells, however, silencing of endogenous p53 alone does not induce centrosome amplification or CIN, although high degrees of correlation between p53 mutation and CIN/centrosome...
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