Article

STAMBP-Mediated K63 Deubiquitination of E2F1 Release E2F1 from RB Repressive Complex to Drive Bladder Cancer Progression

2025-12-18

Abstract excerpt

<title>Abstract</title> <p>The canonical RB1-E2F regulatory model depends on RB phosphorylation-induced allosteric changes during the cell cycle. However, extensive RB mutations across cancers indicate the existence of phosphorylation-independent mechanisms governing RB–E2F complex stability. Here, we report a novel regulatory axis where enhanced E2F1 activity inversely correlates with K63-linked ubiquitination l...

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Literature Corpus work: 6a9f2456-1b20-5aad-9aa7-627e975e0707
DOI: 10.21203/rs.3.rs-8327775/v1

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