Article

Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptors

2024-04-05

Abstract excerpt

Ketamine is an NMDA-receptor antagonist that produces sedation, analgesia and dissociation at low doses and profound unconsciousness with antinociception at high doses. At high and low doses, ketamine can generate gamma oscillations ( > 25 Hz) in the electroencephalogram (EEG). The gamma oscillations are interrupted by slow-delta oscillations (0.1-4 Hz) at high doses. Ketamine’s primary molecular targets and its...

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Literature Corpus work: e46fe2a5-b432-5458-b212-e0c47ec99976
DOI: 10.1101/2024.04.03.587998

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