Article

Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia

2026-06-12

Abstract excerpt

Understanding how receptor-level pharmacological modulation reorganizes large-scale brain circuits remains a central challenge in neuropharmacology. We introduce a multiscale mechanistic model with explicit core–matrix thalamocortical architecture, driven solely by GABA-A modulation without parameter fitting to any anesthesia data, to examine how propofol reorganizes brainwide activity from individual receptors to...

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Literature Corpus work: 035f37e1-f7a3-5039-b06e-3cf77651e59d
DOI: 10.64898/2026.06.10.731411

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